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Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
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A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
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A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Related Experiment Video

Updated: May 12, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

Subacute subdural hematoma.

Satoru Takeuchi1, Yoshio Takasato, Naoki Otani

  • 1Department of Neurosurgery, National Defense Medical College, Saitama, Japan. s.takeuchi@room.ocn.ne.jp

Acta Neurochirurgica. Supplement
|April 9, 2013
PubMed
Summary
This summary is machine-generated.

Subacute subdural hematoma (SASDH) is rare. This study suggests impaired autoregulation causes hyperperfusion, leading to SASDH development and neurological decline.

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Last Updated: May 12, 2026

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
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The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects
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The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

Published on: October 2, 2014

Area of Science:

  • Neurology
  • Neurosurgery
  • Medical Research

Background:

  • Subacute subdural hematoma (SASDH) is an uncommon condition.
  • Understanding its pathogenesis is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical characteristics and potential mechanisms of SASDH.
  • To explore the relationship between cerebral blood flow and SASDH development.

Main Methods:

  • Retrospective review of 8 patients diagnosed with SASDH.
  • Analysis of patient demographics, injury-to-symptom delay, hematoma volume changes, surgical interventions, and outcomes.
  • Assessment of cerebral blood flow in one patient.

Main Results:

  • The study included 8 patients (4 male, 4 female) aged 45-87 years.
  • Neurological deterioration occurred 4-20 days post-injury, with increased hematoma volume in 6 patients.
  • Seven patients underwent surgery, achieving good recovery (4) or moderate disability (4).
  • One patient showed increased cerebral blood flow below the hematoma.

Conclusions:

  • Impaired autoregulation may lead to hyperperfusion in the subacute phase, potentially causing SASDH.
  • This hyperperfusion could explain the observed neurological deterioration.
  • Further research with larger cohorts is required to confirm these findings.