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Assessment of brain compliance using ICP waveform analysis in water intoxication rat model
Kotaro Oshio1, Hidetaka Onodera, Masashi Uchida
1Department of Neurosurgery, St. Marianna University School of Medicine, Kanagawa, Japan. koshio@marianna-u.ac.jp
Abstract:
Intracranial pressure (ICP) monitoring has been used widely for patients with intracranial hypertension. However, the data of mean ICP do not reflect various brain conditions correctly. Therefore, we performed ICP -waveform analysis to assess brain compliance. Data for ICP -waveform analysis were obtained by stereotactic intraventricle puncture. ICP waveform is expressed as a three-phase wave. Analyzed differential waveforms in a water intoxication model and continuous infusion models were evaluated respectively. In the water intoxication models, the second wave (P2) known to reflect compliance is elevated. ICP waveform analysis will be valuable for the assessment of the pathological condition of the brain.
