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Cortical neuron loss in post-traumatic higher brain dysfunction using (123)I-iomazenil SPECT

Jyoji Nakagawara1, Kenji Kamiyama, Masaaki Takahashi

  • 1Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan. nakagawara.joji.hp@mail.ncvc.go.jp

Acta Neurochirurgica. Supplement
|April 9, 2013
PubMed
Summary

Mild traumatic brain injury (MTBI) can cause higher brain dysfunction (HBD). SPECT imaging with (123)I-iomazenil revealed significant cortical neuron loss in the medial frontal lobes of HBD patients, aiding diagnosis.

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...