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Related Experiment Video

Updated: May 12, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

Arterial vascularization patterns of the splenium: An anatomical study.

G Kahilogullari, A Comert, M Ozdemir

Clinical Anatomy (New York, N.Y.)

|April 9, 2013

Summary

Detailed study of the splenium of the corpus callosum (CC) arterial supply reveals complex vascular patterns. Understanding this brain region

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Last Updated: May 12, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

Area of Science:

Neuroanatomy
Vascular Anatomy
Neuroscience

Background:

The splenium of the corpus callosum (CC) is a critical brain structure, forming the largest commissural tract.
Pathologies frequently affect the splenium, yet its precise arterial vascularization remains debated.
Existing literature lacks comprehensive anatomical detail on the splenium's blood supply.

Purpose of the Study:

To elucidate the detailed arterial vascularization of the splenium of the corpus callosum.
To provide anatomical data crucial for understanding and treating splenium-related pathologies.
To address the ongoing debate and inadequacy of current research on this topic.

Main Methods:

Analysis of 30 adult human brains (60 hemispheres) from routine autopsies.
Cannulation and latex injection of cerebral arteries.
Formaldehyde fixation followed by micro-dissection under surgical microscopy.
Measurement of arterial branch diameters at origin and observation of vascularization patterns.

Main Results:

The splenium receives vascular supply from both anterior and posterior circulations.
Anterior pericallosal artery supplies 40% of cases; posterior pericallosal artery (88%) and posterior accessory pericallosal artery (50%) supply posterior circulation.
Vascularization patterns are highly variable between hemispheres and typically involve multiple arterial branches.

Conclusions:

The arterial vascularization of the splenium of the corpus callosum is complex and variable.
This detailed anatomical knowledge is essential for neurosurgical interventions.
Crucial for managing conditions like splenial arteriovenous malformations.