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Independent and conjoint associations of gout and hyperuricaemia with total and cardiovascular mortality

A G Stack1, A Hanley, L F Casserly

  • 1Division of Nephrology, Department of Medicine, University Hospital Limerick, Limerick, Ireland. austin.stack@ul.ie

QJM : Monthly Journal of the Association of Physicians
|April 9, 2013
PubMed

Insights

Gout and high serum uric acid levels independently increase mortality risk. Higher uric acid concentrations further elevate these risks, particularly for cardiovascular events in the general population.

Area of Science:

  • Cardiovascular Health
  • Metabolic Disorders
  • Epidemiology

Background:

  • Gout and elevated serum uric acid are linked to mortality.
  • Their combined impact on mortality in the general population requires further investigation.

Purpose of the Study:

  • To examine the independent and combined effects of gout and serum uric acid on mortality in the U.S. population.

Main Methods:

  • Utilized data from 15,773 U.S. adults (Third National Health and Nutrition Examination Survey).
  • Linked baseline data (1988-1994) with mortality data through 2006.
  • Employed multivariable Cox proportional hazards regression to determine mortality risks.

Main Results:

  • Gout independently increased total mortality (HR 1.42) and cardiovascular mortality (HR 1.58).
  • Each 1 mg/dL increase in uric acid raised total and cardiovascular mortality risks (HR 1.16).
  • Conjoint analysis showed elevated mortality risks with higher uric acid levels in gout patients.

Conclusions:

  • Gout and serum uric acid are independent risk factors for total and cardiovascular mortality.
  • Mortality risk escalates with increasing serum uric acid concentrations.
Abstract

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