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Influence of bacteriophage preparations on migration of HL-60 leukemia cells in vitro
Aneta Kurzepa-Skaradzinska1, Grzegorz Skaradzinski, Beata Weber-Dabrowska
1Laboratory of Bacteriophages, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. aneta.kurzepa@up.wroc.pl
Background:
Bacteriophage therapy is considered one of the most attractive alternatives to antibiotic treatment, which may be significant due to the rising number of antibiotic-resistant bacterial strains. Patients with cancer frequently suffer bacterial infections resulting from immunosuppression caused by anticancer treatment; thus they constitute a considerable group of patients subjected to phage therapy. In this study, we investigated the influence of bacteriophages on the migration of human leukemia (HL-60) cells. Results of these studies provide data regarding phage treatment of patients with cancer, especially with this type of leukemia.
Materials And Methods:
The influence of phage preparation on migration of HL-60 leukemia cells was evaluated with BD Bioscience Migration Chambers.
Results:
Bacteriophages have no influence on migration of HL-60 cells. The only phage preparation which stimulated migration of HL-60 cells was Staph.liz, specific to S. aureus, however, the molecular basis of these interactions cannot be currently explained.
Conclusion:
Results of our studies may be in line with previous data indicating that phage therapy is safe for patients with cancer.
