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Related Concept Videos

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: May 12, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Deep sclerectomy versus trabeculectomy: a morphological study with anterior segment optical coherence tomography.

Aris Konstantopoulos1, Mohammad E Yadegarfar, Ghasem Yadegarfar

  • 1Southampton Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

The British Journal of Ophthalmology
|April 9, 2013
PubMed
Summary

Deep sclerectomy (DS) lowers intraocular pressure (IOP) via trans-conjunctival aqueous percolation. A taller intrascleral lake (IL) and thicker conjunctival/Tenon

Keywords:
GlaucomaImaging

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Last Updated: May 12, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Area of Science:

  • Ophthalmology
  • Glaucoma Surgery
  • Anatomical Imaging

Background:

  • Glaucoma surgery aims to reduce intraocular pressure (IOP).
  • Deep sclerectomy (DS) and trabeculectomy are common glaucoma surgical procedures.
  • Anterior segment optical coherence tomography (AS-OCT) allows detailed visualization of ocular structures.

Purpose of the Study:

  • To elucidate the IOP-lowering mechanisms of deep sclerectomy (DS).
  • To compare AS-OCT parameters between DS, trabeculectomy, and control eyes.
  • To identify AS-OCT features associated with successful glaucoma surgery outcomes.

Main Methods:

  • Prospective cross-sectional study comparing AS-OCT parameters.
  • Analysis included 18 DS, 17 trabeculectomy, and 15 control cases.
  • Correlation of AS-OCT parameters with IOP and surgical success (IOP ≤ 16 mm Hg without medication).

Main Results:

  • Successful DS cases showed a taller intrascleral lake (IL) and thicker conjunctival/Tenon's layer (CTL) compared to unsuccessful cases.
  • CTL thickness correlated negatively with IOP and significantly differed across groups (controls < DS < trabeculectomy).
  • Successful trabeculectomy cases exhibited a taller bleb cavity (BC).

Conclusions:

  • Trans-conjunctival aqueous percolation is a newly identified drainage pathway for DS.
  • The intrascleral lake (IL) in DS functions analogously to the bleb cavity (BC) in trabeculectomy.
  • A substantial postoperative IL and a thick CTL are indicators of favorable surgical outcomes in DS.