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High-density lipoprotein cholesterol: How High

G Rajagopal1, V Suresh, Alok Sachan

  • 1Department of Endocrinology and Metabolism, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh - 517 507, India .

Indian Journal of Endocrinology and Metabolism
|April 9, 2013
PubMed

Insights

High-density lipoprotein cholesterol (HDL-C), the "good cholesterol," is inversely linked to coronary heart disease (CHD) risk. Higher HDL-C levels are associated with significantly lower CHD risk, with no identified upper limit for this protective effect.

Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Preventive Cardiology

Background:

  • High-density lipoprotein cholesterol (HDL-C) is recognized as

Purpose of the Study:

  • To review the relationship between HDL-C levels and coronary heart disease (CHD) risk.
  • To discuss the implications for treating low HDL-C and the role of emerging therapies.

Main Methods:

  • Review of epidemiological studies correlating HDL-C levels with CHD risk.
  • Analysis of the established benefits of statins.
  • Overview of cholesteryl ester transfer protein (CETP) inhibitors in HDL metabolism.

Main Results:

  • A clear inverse relationship exists between HDL-C levels and CHD risk.
  • Higher HDL-C concentrations (above 60 mg/dL) are associated with progressively lower CHD risk.
  • No upper limit for the beneficial effect of HDL-C on CHD risk has been determined.

Conclusions:

  • Elevated HDL-C levels are protective against coronary heart disease.
  • While statins improve CHD outcomes, the therapeutic targets for low HDL-C remain under investigation.
  • Cholesteryl ester transfer protein (CETP) inhibitors are a potential therapeutic avenue, but their clinical utility requires further evaluation.

Keywords:
High-density lipoprotein cholesterolcardiovascular riskcholesteryl ester transfer protein inhibitors

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