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Calibration Procedures for Orthogonal Superposition Rheology

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Published on: November 18, 2020

Where do conventional OADs stand.

Rakesh Kumar Sahay¹, V Sri Nagesh

¹Department of Endocrinology, Osmania Medical College & Hospital, Hyderabad, India.

Indian Journal of Endocrinology and Metabolism

|April 9, 2013

Summary

This summary is machine-generated.

The past 20 years saw many new oral antidiabetic drugs (OADs). This review examines OADs, focusing on sulfonylureas, considering newer agents and common concerns like cardiovascular safety and hypoglycemia.

Keywords:

Conventional OADs new roles sulfonylureas

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Area of Science:

Endocrinology
Pharmacology
Internal Medicine

Background:

The last two decades have seen significant advancements in oral antidiabetic drugs (OADs).
Concerns regarding OADs include cardiovascular safety, hypoglycemia risk, and weight gain.
The emergence of novel OADs necessitates a re-evaluation of established treatments.

Purpose of the Study:

To review oral antidiabetic drugs (OADs).
To specifically analyze sulfonylureas in comparison to newer antidiabetic agents.
To address key safety and efficacy concerns associated with OADs.

Main Methods:

Literature review of oral antidiabetic drugs.
Comparative analysis of sulfonylureas and newer OAD classes.
Evaluation of safety profiles, including cardiovascular events and hypoglycemia.

Main Results:

Newer OADs offer improved safety profiles regarding cardiovascular events and hypoglycemia compared to older agents.
Sulfonylureas, while effective, carry a higher risk of hypoglycemia and potential weight gain.
The choice of OAD depends on individual patient profiles and risk factors.

Conclusions:

Oral antidiabetic drug development has rapidly advanced, offering diverse therapeutic options.
Sulfonylureas remain a treatment option but require careful consideration of their risks.
Personalized medicine approaches are crucial for optimizing OAD selection and patient outcomes.