Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultrasound-Guided Percutaneous Ethanol Injection for the Treatment of Cystic and Predominantly Cystic Thyroid Nodules: A Single-Centre Experience.

Indian journal of endocrinology and metabolism·2026
Same author

Bardet-Biedl Syndrome in India: Genotypic Spectrum and Clinical Features From a Single-Centre Cohort.

Clinical endocrinology·2026
Same author

Lean Body Mass as a Predictor of Levothyroxine Requirement in Primary Hypothyroidism as Compared to Actual Body Weight.

Journal of the Endocrine Society·2025
Same author

Age of Puberty Onset among Healthy Schoolgirls in North Karnataka: A Cross Sectional Study.

Indian journal of endocrinology and metabolism·2025
Same author

Gallbladder reporting and data system (GB-RADS) for risk stratification of gallbladder wall thickening on ultrasonography: an international expert consensus.

Abdominal radiology (New York)·2021
Same author

Effect of Monochromatic Infrared Energy on Quality of Life and Intraepidermal Nerve Fiber Density in Painful Diabetic Neuropathy: A Randomized, Sham Control Study.

Neurology India·2021

Related Experiment Video

Updated: May 12, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Empty sella syndrome - beyond being an incidental finding.

Vikrant Ghatnatti1, Dipti Sarma, Uma Saikia

  • 1Department of Endocrinology, Gauhati Medical College, Guwahati, India.

Indian Journal of Endocrinology and Metabolism
|April 9, 2013
PubMed
Summary

Empty sella, a condition involving pituitary gland flattening, frequently presents with endocrine dysfunction, particularly in primary empty sella cases. Early hormonal evaluation is crucial for timely treatment and improved patient quality of life.

Keywords:
Empty sellaHyperprolactinemiaisolated Growth Hormone Deficiency

More Related Videos

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Related Experiment Videos

Last Updated: May 12, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Surgical Treatment of an Endolymphatic Sac Tumor
04:34

Surgical Treatment of an Endolymphatic Sac Tumor

Published on: May 26, 2023

Area of Science:

  • Endocrinology
  • Radiology
  • Internal Medicine

Background:

  • Empty sella is defined by subarachnoid space herniation into the sella, often causing pituitary gland flattening.
  • This condition necessitates evaluation of its clinical and hormonal impact.

Purpose of the Study:

  • To assess the clinical and hormonal profiles of patients diagnosed with empty sella.
  • To identify the prevalence and types of endocrine dysfunctions associated with empty sella.

Main Methods:

  • Retrospective analysis of 34 patients with radiologically confirmed empty sella (CT/MRI).
  • Detailed clinical history, examination, and comprehensive hormonal evaluation including TSH, T4, cortisol, prolactin, testosterone, FSH, LH, and IGF-1.
  • Categorization into primary empty sella (PES) and secondary empty sella (SES).

Main Results:

  • 50% of patients with primary empty sella (12/24) exhibited endocrine dysfunction.
  • Hyperprolactinemia was the most frequent endocrine abnormality (20.8%, 5/24).
  • Isolated growth hormone (GH) deficiency was the most common hormonal deficit (12.5%, 4/24).

Conclusions:

  • A high incidence of endocrine abnormalities, especially in primary empty sella, warrants routine endocrine screening.
  • Early detection and management of hormonal deficiencies are essential for improving patient outcomes and quality of life.