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Mild acute pancreatitis with vildagliptin use
Ravikant Saraogi1, Ritwika Mallik, Sujoy Ghosh
1Calcutta Medical Research Institute, West Bengal, India.
Indian Journal of Endocrinology and Metabolism
|April 9, 2013
Summary
A rare case of acute pancreatitis in a diabetic patient was likely caused by vildagliptin, a DPP-4 inhibitor. This suggests a potential class effect for these diabetes medications.
Area of Science:
- Endocrinology
- Gastroenterology
- Pharmacology
Background:
- Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used for type 2 diabetes management.
- Postmarketing surveillance has rarely linked vildagliptin to acute pancreatitis.
- This report details a case from India, a region with high diabetes prevalence.
Observation:
- A 42-year-old male diabetic patient on vildagliptin and metformin developed severe abdominal pain, nausea, and fever.
- Elevated serum pancreatic enzymes and characteristic ultrasound findings indicated acute pancreatitis.
- Alcohol use and hypertriglyceridemia, common pancreatitis causes, were absent.
Findings:
- Vildagliptin was discontinued, leading to the resolution of acute pancreatitis.
- No other secondary causes for pancreatitis were identified during follow-up.
- This case represents the first reported instance of vildagliptin-associated pancreatitis in India.
Implications:
- The findings suggest vildagliptin may be a potential, albeit rare, cause of acute pancreatitis.
- This raises concerns about a possible class effect among DPP-4 inhibitors.
- Further investigation into the safety profile of DPP-4 inhibitors regarding pancreatitis is warranted.
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