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Ionic Association01:28

Ionic Association

The ionic association is the association of oppositely charged ions in an electrolyte solution to form ion pairs. Bjerrum defined ion pairs as two oppositely charged ions whose electrostatic attraction exceeds the thermal energy of the system, typically expressed as 2kT. Electrostatic attraction depends on ionic charge, separation distance, and the dielectric constant of the medium. Thermal energy, represented by kT, reflects the tendency of ions to move independently due to molecular motion.
Energy Associated With a Charge Distribution01:21

Energy Associated With a Charge Distribution

The work done to bring a charge through a distance r is given by the potential difference between the initial and the final position. To assemble a collection of point charges, the total work done can be expressed in terms of the product of each pair of charges divided by their separation distance, defined with respect to a suitable origin. Solving this expression gives the energy stored in a point charge distribution.
The Electrical Double Layer01:30

The Electrical Double Layer

In the region where two bulk phases meet, an intricate electric charge distribution arises due to charge transfer, ion adsorption, molecular orientation, and charge distortion. This complex distribution is commonly referred to as the electrical double layer.When a solid electrode interfaces with ions in an electrolyte solution, the speed of electron transfer dictates the rates of oxidation and reduction. The electrode acquires a charge through the escape of atoms into the solution as cations or...
Charging Conductors By Induction01:15

Charging Conductors By Induction

The Earth is a good conductor of electricity, and it is so big that it can be considered an infinite source or sink of charges. It can easily exchange charges with any matter.
Generally, conductors like metals do not allow any excess charge to be present on them. Any excess charge added to metals easily flows away, for example, when a metal is placed on the Earth. This process is called earthing.
However, conductors can be charged by a process called induction. For example, consider charging a...
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Intermolecular Forces03:13

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...

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Updated: May 12, 2026

Associated Chromosome Trap for Identifying Long-range DNA Interactions
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Associated Chromosome Trap for Identifying Long-range DNA Interactions

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CHARGE Association.

Semanti Chakraborty1, Jayanta Chakraborty

  • 1Department of Endocrinology, IPGMER, Kolkata, West Bengal, India.

Indian Journal of Endocrinology and Metabolism
|April 9, 2013
PubMed
Summary
This summary is machine-generated.

This case study describes a 17-year-old boy with CHARGE association, highlighting his complex congenital anomalies and hypogonadotrophic hypogonadism. The findings emphasize the importance of recognizing this syndrome in patients with multiple birth defects.

Keywords:
CHARGEHypogonadotrophic hypogonadismcongenital malformations

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Area of Science:

  • Pediatric Endocrinology
  • Clinical Genetics
  • Congenital Anomalies

Background:

  • CHARGE association is a recognized pattern of congenital anomalies.
  • It comprises coloboma, heart defect, choanal atresia, retarded growth and development, genital hypoplasia, ear abnormalities, and/or deafness.
  • This case presents a detailed clinical picture of a patient with CHARGE association.

Observation:

  • A 17-year-old male presented with obesity, bilateral gynecomastia, mental retardation, and hypogonadotrophic hypogonadism.
  • Physical examination revealed facial asymmetry, genital hypoplasia, undescended testes, and choanalatresia.
  • Laboratory results showed decreased IGF1 and testosterone, with elevated prolactin; karyotype was 46XY.

Findings:

  • Imaging revealed a small pituitary gland, undescended testes, and choanalatresia.
  • Sonomammography indicated bilateral fibroglandular proliferation in the breasts.
  • The patient exhibited a constellation of anomalies consistent with CHARGE association.

Implications:

  • This case underscores the phenotypic variability within CHARGE association.
  • Early recognition and comprehensive management are crucial for affected individuals.
  • Further research into the genetic and molecular underpinnings of CHARGE association is warranted.