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The relationship between inflammatory and oxidative stress biomarkers, atherosclerosis and rheumatic diseases

Corina Şerban, Simona Drăgan1

  • 1Department of Functional Sciences, University of Medicine and Pharmacy "Victor Babes" Timisoara, Romania. dr.corinaserban@yahoo.com.

Current Pharmaceutical Design
|April 10, 2013
PubMed

Insights

Atherosclerotic cardiovascular disease, a leading cause of death, involves complex cell interactions. This study explores blood biomarkers for cardiovascular risk and rheumatic disease progression, focusing on inflammation and oxidative stress.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Rheumatology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) is a major global cause of mortality.
  • ASCVD pathogenesis involves intricate interactions between immune and vascular cells, influenced by oxidative stress and inflammation.
  • Current research seeks novel biomarkers (blood-based, genetic, metabolomic) for early detection and risk prediction.

Purpose of the Study:

  • To review the role of circulating inflammatory and oxidative stress biomarkers in atherosclerotic cardiovascular disease.
  • To evaluate the potential of these biomarkers for screening cardiovascular risk.
  • To assess their utility in predicting the progression of associated rheumatic diseases.

Main Methods:

  • Literature review focusing on biomarker discovery in cardiovascular disease and rheumatic conditions.
  • Analysis of studies investigating inflammatory and oxidative stress markers.
  • Synthesis of evidence on the predictive value of biomarkers for cardiovascular events and rheumatic disease evolution.

Main Results:

  • Inflammatory and oxidative stress markers are implicated in both atherosclerosis and rheumatic diseases.
  • Certain biomarkers show promise for identifying individuals at high cardiovascular risk.
  • These markers may also offer insights into the interplay between systemic inflammation and cardiovascular health in rheumatic patients.

Conclusions:

  • Circulating biomarkers related to inflammation and oxidative stress hold potential for integrated cardiovascular risk assessment and management in rheumatic diseases.
  • Further research is needed to validate these biomarkers for routine clinical use in predicting cardiovascular events and disease progression.
  • Understanding these overlaps can lead to improved patient outcomes through personalized medicine approaches.

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