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Psoriasis and atherosclerosis: Is there a need for novel biomarkers assessing cardiovascular risk?

Murat Sunbul, Mehmet Agirbasli1

  • 1Yesilbahar Sok. 68/14 Goztepe 34726 Istanbul Turkey. magirbasli@gmail.com.

Current Pharmaceutical Design
|April 10, 2013
PubMed

Insights

Patients with psoriasis and psoriatic arthritis (PsA) face higher mortality, mainly from coronary artery disease. Novel biomarkers can help identify and manage cardiovascular disease (CVD) risk in these patients.

Area of Science:

  • Dermatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis and psoriatic arthritis (PsA) are linked to increased mortality.
  • Coronary artery disease (CVD) is the primary cause of excess mortality in these patients.
  • Psoriatic disease necessitates considering patients as a high-risk population for CVD.

Purpose of the Study:

  • To review biomarkers and mediators of cardiovascular risk in psoriasis and PsA.
  • To analyze the relationship between psoriasis and novel vascular biomarkers.
  • To explore strategies for preventive studies in psoriatic patients.

Main Methods:

  • Systematic literature search of Medline/PubMed.
  • Inclusion of studies on cardiovascular disease (CVD), risk factors, and inflammatory markers.
  • Analysis of the association between psoriasis and vascular biomarkers.

Main Results:

  • Psoriatic patients represent a high-risk group for CVD.
  • Novel biomarkers of inflammation, thrombosis, oxidative stress, and atherosclerosis are identified.
  • These biomarkers aid in risk stratification for early CVD detection and treatment.

Conclusions:

  • Understanding the link between psoriasis and vascular risk is crucial.
  • Biomarkers offer potential for improved CVD management in psoriatic patients.
  • Early detection and treatment strategies can mitigate CVD morbidity and mortality.

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