Related Experiment Video
Updated: May 12, 2026
Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
Skin conductance variations compared to ABC scale for pain evaluation in newborns
Rosa T Scaramuzzo1, Maddalena Faraoni, Elisa Polica
1UO Neonatologia, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. rosa.scaramuzzo@gmail.com
Objectives:
To validate spontaneous skin conductance variations as a specific reliable mean to measure pain in full-term healthy newborns during heel stick, comparing it with the ABC scale. To compare oral sucrose to wrapping effectiveness for non-pharmacological analgesia during the same procedure.
Method:
All recruited newborns (n = 158) underwent a heel stick for metabolic screening at 48 h of life with non-pharmacological analgesia by oral sucrose (group A) or wrapping (group B) according to randomization. Their pain was estimated by ABC scale score (standard method) and measured by skin conductance variations.
Results:
A positive correlation was founded between peaks per sec measure and ABC score (rs = 0.303, p < 0.005). ABC score in group A was lower than in group B (p < 0.001). Difference in mean ABC score among newborn subgroups treated by different nurses was not statistically significant for wrapping while it was significant for sucrose (p = 0.001).
Conclusions:
Skin conductance measurement device is a reliable method to evaluate pain. Novel technological devices may be a useful support to clinical observation in this field. Oral sucrose is more effective than wrapping in reducing pain. Operators should be well periodically re-trained in performing non pharmacological analgesia during minor procedure on newborns.
