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Updated: May 12, 2026

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
Transcriptional and epigenetic networks in the development and maturation of dendritic cells
Hyoung-Pyo Kim1, Yeon-Su Lee, Jong Hoon Park
1Department of Environmental Medical Biology, Institute of Tropical Medicine, & Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea. kimhp@yuhs.ac
Abstract:
Dendritic cells (DCs) are professional antigen-presenting cells that provide a critical link between the innate and adaptive immune responses. The genetic program required for differentiation of DCs from their hematopoietic precursors is controlled by both cytokines and transcription factors. The signals transduced from cytokines recruit specific transcription factors, enabling the expression of a distinct transcriptome that is required for specification of different DC lineages. The establishment of a distinct transcriptome also depends on chromatin modifications associated with critical cis elements of lineage-specific genes. In this review, recent advances in the understanding of the transcriptional network governing DC lineage specification are summarized, along with current views of the dynamic DC epigenome.
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