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[Atherogenicity indices and coronary risk]
O Kusá1, O Luknárová, I Riecanský
1Kardiologická klinika Ustavu kardiovaskulárnych chorôb, Bratislava.
Insights
The HDL-cholesterol to total cholesterol ratio best identifies coronary risk in men with stable angina. Another index effectively measures atherosclerotic stenosis severity in these patients.
Area of Science:
- Cardiology
- Biochemistry
- Medical Diagnostics
Context:
- Ischaemic heart disease, specifically stable angina pectoris, affects numerous men.
- Accurate assessment of coronary risk and atherosclerotic stenosis is crucial for patient management.
- Existing atherogenicity indices require evaluation for their clinical utility.
Purpose:
- To compare three atherogenicity indices in men with stable angina pectoris.
- To determine the best index for evaluating coronary risk.
- To identify the most effective index for assessing atherosclerotic stenosis severity.
Summary:
- This study compared three atherogenicity indices in 120 men with stable angina and 30 controls.
- The HDL-cholesterol:total cholesterol ratio was identified as the superior index for coronary risk evaluation, differentiating patients from controls (r = -0.54, p < 0.001).
- The VLDL-cholesterol + LDL-cholesterol:HDL-cholesterol ratio proved best for assessing atherosclerotic stenosis severity in patients with stable angina (r = 0.24, p < 0.05).
Impact:
- Provides clinicians with validated tools for risk stratification and severity assessment in stable angina.
- Highlights the importance of specific lipid ratios in cardiovascular disease evaluation.
- Contributes to improved diagnostic strategies for coronary artery disease.
Abstract:
The authors compared three different indices, of atherogenicity in 120 men with ischaemic heart disease, type stable angina pectoris (mean age 35.9 +/- 7.54 years) with 30 men of a control group--mean age 42.1 +/- 8.89 years). They evaluated relationship between the atherogenicity index and coronary score by the Spearman correlation coefficient. They consider the index HDL-cholesterol: total cholesterol the best index for evaluation of the coronary risk. This index differentiates men with ischaemic heart disease, type stable angina pectoris with a positive coronary score from the control group of men with a negative coronary score (r = -0.54, p less than 0.001). The index VLDL-cholesterol + LDL-cholesterol: HDL-cholesterol is the best index for evaluation of the severity of atherosclerotic stenosis of the coronary arteries in men with ischaemic heart disease, type stable angina. This index differentiated probands with a different score (r = 0.24, p less than 0.05).