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Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
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Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

Thymoma with molecularly verified "conversion" to T lymphoblastic leukemia/lymphoma over 9 years

Vera Ertel1, Martin Früh, Alexander Guenther

  • 1Department of Pathology.

Leukemia & Lymphoma
|April 10, 2013
PubMed
Abstract

No abstract available in PubMed .

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...