Related Experiment Video
Updated: May 12, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Troponin T in acute ischemic stroke.
Michal Král1, Daniel Šaňák, Tomáš Veverka
1Comprehensive Stroke Center, Department of Neurology, University Hospital and Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
The American Journal of Cardiology
|April 10, 2013
Summary
Elevated cardiac troponin T (cTnT) is common in acute ischemic stroke (AIS) patients. Creatinine, NT-proBNP, and CK-MB levels predict cTnT elevation, indicating potential cardiac issues requiring further investigation.
Area of Science:
- Cardiology
- Neurology
- Clinical Chemistry
Background:
- Cardiovascular and cerebrovascular diseases often interact.
- Cardiac troponin T (cTnT) is a biomarker for myocardial injury.
- Acute ischemic stroke (AIS) can have cardiac implications.
Purpose of the Study:
- To assess serum cTnT levels in AIS patients.
- To identify factors associated with elevated cTnT in AIS.
- To evaluate the need for further cardiac investigation in AIS.
Main Methods:
- Prospective observational study of 107 AIS patients admitted within 12 hours.
- Neurologic exams, brain imaging, ECG, and laboratory tests including cTnT and cardiac markers.
- Correlation and multivariate regression analyses to identify predictors of cTnT elevation.
Main Results:
- 36.4% of AIS patients had elevated cTnT.
- cTnT levels correlated with age, NT-proBNP, cystatin C, CK-MB, urea, and albumin.
- Elevated creatinine, NT-proBNP, and CK-MB were independent predictors of elevated cTnT.
Conclusions:
- Elevated cTnT is frequent in AIS patients.
- Specific biomarkers (creatinine, NT-proBNP, CK-MB) are associated with cTnT elevation.
- Further clinical evaluation is necessary to confirm acute myocardial impairment in AIS patients with elevated cTnT.
Related Concept Videos
01:26Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
01:30Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:15Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
01:15Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...