Related Experiment Video

Updated: May 12, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

[Purpura fulminans, venous thrombosis and constitutional thrombophilia in an infant]

F Fadil1, F Elfatoiki, K Mortaji

  • 1Service de pédiatrie 3, hôpital d'enfant, CHU Ibn Rochd, Casablanca, Maroc. fz.fadi@gmail.com

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|April 10, 2013
PubMed

Insights

Idiopathic purpura fulminans (PF) and venous thrombosis (VT) in infants are rarely linked to inherited clotting disorders. A case highlights a Factor II mutation as a cause, emphasizing early diagnosis and multidisciplinary care.

Area of Science:

  • Pediatrics
  • Hematology
  • Genetics

Background:

  • Idiopathic purpura fulminans (PF) and venous thrombosis (VT) are rare conditions in infants.
  • Constitutional thrombophilia is seldom identified as a cause in this age group.

Observation:

  • An 18-month-old infant presented with PF and lower limb VT.
  • Laboratory tests revealed disseminated intravascular coagulation (DIVC) with normal protein C, protein S, and antithrombin levels.
  • Genetic testing identified a heterozygous Factor II (G 20210A) mutation.

Findings:

  • The infant's condition was attributed to a heterozygous Factor II (G 20210A) mutation.
  • This genetic finding provides a potential explanation for the co-occurrence of PF and VT in the infant.

Implications:

  • Highlights the importance of genetic testing for thrombophilia in infants with unexplained PF and VT.
  • Underscores the need for a multidisciplinary approach in managing these complex cases.
  • Suggests Factor II mutation as a potential, though rare, underlying cause in pediatric thrombosis and purpura fulminans.

More Related Videos

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats04:12

Modeling Posthemorrhagic Hydrocephalus of Prematurity in Rats

Published on: March 28, 2025

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...