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Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?01:04

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?00:56

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...

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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast

Published on: September 26, 2025

Cell cycle control across the eukaryotic kingdom.

Hirofumi Harashima1, Nico Dissmeyer, Arp Schnittger

  • 1Department of Molecular Mechanisms of Phenotypic Plasticity, Institut de Biologie Moléculaire des Plantes du Centre National de la Recherche Scientifique, Université de Strasbourg, F-67084 Strasbourg, France.

Trends in Cell Biology
|April 10, 2013
PubMed
Summary
This summary is machine-generated.

Comparing cell cycle regulation across diverse eukaryotic life, this study reveals conserved functions and evolutionary dynamics in flowering plants versus animal and fungal systems. This broadens our understanding of eukaryotic cell cycle evolution.

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Area of Science:

  • Eukaryotic cell biology
  • Evolutionary biology
  • Genetics

Background:

  • Eukaryotic life exhibits vast diversity, with cell cycle control crucial for growth and reproduction.
  • Current understanding of cell cycle regulation primarily stems from a limited number of unikont model species.
  • Investigating distantly related clades offers insights into general cell cycle principles and evolutionary patterns.

Purpose of the Study:

  • To compare central cell cycle regulator functions between non-unikont (flowering plants) and unikont (animal/fungal) systems.
  • To analyze the structural differences in cell cycle regulatory network topologies across these groups.
  • To examine the evolutionary dynamics of core cell cycle kinase substrates.

Main Methods:

  • Comparative analysis of cell cycle regulator functions.
  • Network topology analysis of cell cycle regulatory pathways.
  • Evolutionary analysis of core cell cycle kinase substrates.

Main Results:

  • Identified conserved functions of key cell cycle regulators across diverse eukaryotic clades.
  • Revealed variations in cell cycle network topologies between plant and animal/fungal systems.
  • Characterized the evolutionary dynamics of substrates targeted by core cell cycle kinases.

Conclusions:

  • Comparative studies across distantly related eukaryotes are essential for understanding universal cell cycle principles.
  • The evolution of cell cycle regulation shows both conserved core mechanisms and clade-specific adaptations.
  • Flowering plants provide a valuable non-unikont system for studying cell cycle evolution.