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Updated: May 12, 2026

Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Postsurgical intrapericardial adhesions: mechanisms of formation and prevention
Aldo Cannata1, Duccio Petrella, Claudio Francesco Russo
1Department of Cardiac Surgery, Niguarda Ca' Granda Hospital, Milan, Italy. aldo.cannata@ospedaleniguarda.it
Abstract:
Postsurgical intrapericardial adhesions are still considered an unavoidable consequence of cardiothoracic operations. They increase the technical difficulty and the risk of reoperations. The pathogenesis of postsurgical adhesions is a multistep process, and the main key players are (1) loss of mesothelial cells, (2) accumulation of fibrin in areas devoid of mesothelial cells, (3) loss of normal pericardial fibrinolysis, and (4) local inflammation. Today, very promising methods to reduce adhesions are available for clinical use. This report reviews the process of formation of adhesions and the methods to prevent them, classified according to the mechanism of action.
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