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Cannabinoid signaling and liver therapeutics

Ariane Mallat1, Fatima Teixeira-Clerc, Sophie Lotersztajn

  • 1INSERM, U955, Créteil 94000, France; Université Paris-Est, UMR-S955, UPEC, Créteil 94000, France; AP-HP, Hôpital H. Mondor-A. Chenevier, Dept d'Hépatologie et de Gastroentérologie, Créteil 94000, France.

Journal of Hepatology
|April 10, 2013
PubMed
Summary

The endocannabinoid system impacts liver injury. Targeting CB1 and CB2 receptors shows promise for treating liver diseases like NAFLD and fibrosis, with peripherally-restricted drugs offering a safer therapeutic avenue.

Keywords:
CB1CB2Endocannabinoid systemFatty liver diseaseFibrosisInflammation.Kupffer cellsLiver regenerationSteatosis

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