Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose Response Curve: Conventional Versus Nonmonotonic01:21

Dose Response Curve: Conventional Versus Nonmonotonic

The correlation between a drug's dosage and its impact on a biological system is a cornerstone of pharmacology and toxicology. Conventional dose–response curves, which include graded and quantal relationships, are key to this understanding. Graded dose–response curves depict the spectrum of a biological reaction to different doses within an individual, indicating that as the drug dosage increases, so does the intensity of the response. On the other hand, quantal dose–response relationships...
Dose-Response Relationship: Overview01:03

Dose-Response Relationship: Overview

Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it produces...
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and β2-adrenergic receptors...
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Dosimetry of DNA Adducts in Mice Exposed to Ethylene Oxide.

Toxicological sciences : an official journal of the Society of Toxicology·2026
Same author

Molecular dosimetry of hemoglobin adducts in mice exposed to ethylene oxide.

Archives of toxicology·2026
Same author

Occupational exposure limit variability and hazard characterization alignment-implications for protection from respiratory irritation.

Journal of occupational and environmental hygiene·2026
Same author

Sensitive Quantification of the Ethylene Oxide Hemoglobin Adduct <i>N</i>-(2-Hydroxyethyl)-l-valine from Minimal Blood Volumes.

Chemical research in toxicology·2026
Same author

Response to Mr. DiNardo's "Letter to the Editor: Comprehensive review of octocrylene toxicology data and human exposure assessment for personal care products".

Critical reviews in toxicology·2026
Same author

Investigation of mode-of-action and human relevance of cumene-induced mouse liver tumors.

Journal of toxicology and environmental health. Part B, Critical reviews·2026
Same journal

Cardiovascular toxicity as a globally harmonized system hazard trait: The evidence and the path forward.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

The NTP Chronic Inhalation Study Does Not Support an Inherent Lung Cancer Hazard of Talc: Implications of Lung Particle Overload and Maximum Tolerated Dose.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Consideration of Carcinogenicity and Mode of Action Information by an Independent Expert Panel to Support Derivation of No-Significant-Risk-Level Values for Vinyl Acetate Monomer.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Which carcinogenicity study should I use? Automated identification of reliable studies.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Adoption of artificial intelligence in drug review across the lifecycle: Transformation of regulatory decision-making.

Regulatory toxicology and pharmacology : RTP·2026
Same journal

Cardiovascular outcomes following intrauterine and lactational exposure to cyantraniliprole in male Wistar rats.

Regulatory toxicology and pharmacology : RTP·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ &alpha; and &beta; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

A framework for fit-for-purpose dose response assessment.

M E Bette Meek1, Michael Bolger, James S Bus

  • 1R. Samuel McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, One Stewart Street, Suite 309, Ottawa, ON K1N 6N5, Canada. bmeek@uottawa.ca

Regulatory Toxicology and Pharmacology : RTP
|April 10, 2013
PubMed
Summary
This summary is machine-generated.

A new framework guides chemical risk assessors in selecting appropriate dose-response assessment methods. This enhances technical analysis and decision-making utility for regulatory agencies like the U.S. Environmental Protection Agency.

More Related Videos

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System
06:25

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System

Published on: January 12, 2024

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ &alpha; and &beta; Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System
06:25

Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System

Published on: January 12, 2024

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Area of Science:

  • Environmental Science
  • Toxicology
  • Risk Assessment

Background:

  • The National Research Council (NRC) report "Science and Decisions" recommended improvements for chemical risk assessment.
  • Key recommendations focused on enhancing chronic dose-response assessments and improving the utility of risk assessment for decision-making.

Purpose of the Study:

  • To advance discussions from the NRC report by exploring available and evolving risk assessment methodologies.
  • To develop a practical framework to guide risk assessors and managers in selecting appropriate dose-response assessment methods.

Main Methods:

  • Three multi-stakeholder workshops were organized by the Alliance for Risk Assessment.
  • Case studies were developed and applied to evaluate risk assessment methodologies.
  • A framework was created to link decision contexts with relevant dose-response assessment methods.

Main Results:

  • A user-friendly framework was developed to guide the selection of dose-response assessment methodologies.
  • The framework addresses various decision contexts, from priority setting to full risk assessments.
  • Case studies illustrate the application of diverse methods, including those for susceptible populations and background exposures.

Conclusions:

  • The developed framework facilitates the organization and communication of methodologies for dose-response analysis.
  • It supports the incorporation of biologically informed and chemical-specific knowledge.
  • This contributes to evolving "fit-for-purpose" risk assessments tailored to specific problem formulations.