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Updated: May 12, 2026
09:46
Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells
Published on: January 20, 2023
Building blood vessels in development and disease
Erich J Kushner1, Victoria L Bautch
1Department of Biology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Current Opinion in Hematology
|April 10, 2013
Summary
Developmental angiogenesis processes become dysfunctional in tumors, creating abnormal tumor endothelial cells. These tumor cells are permanently modified, differing significantly from normal cells.
Area of Science:
- Cell Biology
- Vascular Biology
- Oncology
Background:
- Developmental angiogenesis is crucial for forming blood vessels.
- Tumor growth relies on the formation of new blood vessels.
Purpose of the Study:
- To review developmental angiogenesis.
- To examine tumor-induced changes in endothelial cells.
Main Methods:
- Literature review of angiogenesis and tumor biology.
- Analysis of endothelial cell modifications in tumor environments.
Main Results:
- Tumor environments disrupt normal angiogenesis, leading to abnormal tumor endothelial cells.
- Tumor endothelial cells exhibit permanent modifications compared to normal cells.
Conclusions:
- Tumors hijack developmental angiogenesis pathways.
- Dysregulated signaling in tumors causes endothelial cell dysfunction and permanent alterations.
- Altered tumor endothelial cells may constitute a significant cellular population.
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