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Related Experiment Video

Updated: May 12, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Neuroanatomic pathways associated with poststroke affective and apathetic depression.

Taro Murakami1, Seiji Hama, Hidehisa Yamashita

  • 1Department of Neurosurgery, Graduate School of Biomedical Science, Hiroshima University, Japan.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
|April 10, 2013
PubMed
Summary

Post-stroke depression and apathy involve distinct brain lesion locations. Affective symptoms link to the brainstem and basal ganglia, while apathy is associated with the brainstem and striatum, suggesting different neuroanatomic pathways.

Keywords:
Apathydepressionmagnetic resonance imagingmonoamine pathwaystatistical parametric mapstroke

Related Experiment Videos

Last Updated: May 12, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

  • Neuroimaging
  • Neurology
  • Psychiatry

Background:

  • Post-stroke depression is a common and debilitating complication.
  • Affective and apathetic symptoms can occur independently after stroke.
  • Understanding the neuroanatomic basis of these symptoms is crucial for targeted treatment.

Purpose of the Study:

  • To localize brain lesions associated with affective and apathetic symptoms in post-stroke patients.
  • To investigate the relationship between lesion location and symptom presentation using advanced neuroimaging analysis.
  • To differentiate the neuroanatomic correlates of affective versus apathetic symptoms post-stroke.

Main Methods:

  • Magnetic resonance imaging (MRI) was performed on 149 post-stroke patients.
  • Patients were assessed for affective and apathetic symptoms using validated scales (Hospital Anxiety and Depression Scale, Apathy Scale).
  • Statistical parametric mapping (SPM) was employed to analyze lesion overlap and correlate with symptom severity.

Main Results:

  • Lesion overlap for higher depressive scores was observed in the brainstem, left basal ganglia, and left frontal cortex.
  • Lesion overlap for higher apathy scores was found in the brainstem and bilateral striatum.
  • While the brainstem showed overlap for both, affective and apathetic depression lesion locations often did not coincide.

Conclusions:

  • Affective and apathetic symptoms post-stroke appear linked to distinct neuroanatomic pathways.
  • These pathways are hypothesized to involve different monoaminergic systems (serotonergic for affective, dopaminergic for apathy).
  • Findings highlight the need for differential diagnosis and treatment strategies for post-stroke mood disturbances.