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Going beyond antidepressant monotherapy for incomplete response in nonpsychotic late-life depression: a critical
Donovan T Maust1, David W Oslin, Michael E Thase
1Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Abstract:
Many older adults with major depressive disorder (MDD) do not respond to antidepressant monotherapy. Although there are evidence-based treatment options to support treatment beyond monotherapy for adults, the evidence for such strategies, specifically in late-life MDD, is relatively scarce. This review examines the published data describing strategies for antidepressant augmentation or acceleration studied specifically in older adults, including lithium, stimulants, and second-generation antipsychotics. In addition, the authors suggest strategies for future research, such as study of specific agents, refining understanding of the impact of medical or cognitive comorbidity in late-life depression, and comparative effectiveness to examine methods already used in clinical practice.
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