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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Subclinical atherosclerosis, endothelial function, and serum inflammatory markers in chronic kidney disease stages 3

Shirin Ghanavatian1, Lien My Diep, Peter Bárány

  • 11Department of Cardiology, Oslo University Hospital Ullevål, Oslo University, Oslo, Norway.

Angiology
|April 10, 2013
PubMed

Insights

Patients with chronic kidney disease (CKD) show increased brachial intima-media thickness (bIMT) and inflammatory markers. Estimated glomerular filtration rate (eGFR) is the best predictor of bIMT in these patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Inflammation Research

Background:

  • Chronic kidney disease (CKD) is associated with increased cardiovascular risk.
  • Vascular dysfunction and inflammation are key contributors to CKD complications.

Purpose of the Study:

  • To investigate brachial intima-media thickness (bIMT) and inflammatory markers in CKD patients.
  • To explore the relationship between bIMT, inflammation, and estimated glomerular filtration rate (eGFR) in CKD.

Main Methods:

  • Cross-sectional study comparing 50 CKD stages 3-4 patients with 35 controls.
  • Measurements included inflammatory markers, brachial artery flow-mediated dilatation (FMD), and bIMT.
  • Statistical analyses correlated bIMT with inflammatory markers and eGFR.

Main Results:

  • CKD patients had significantly increased bIMT compared to controls (0.43 mm vs 0.34 mm).
  • No significant difference in FMD was observed between groups.
  • bIMT correlated significantly with high-sensitive C-reactive protein, vascular cellular adhesion molecule 1, tumor necrosis factor, and interleukin 6.
  • Adjusted eGFR was the strongest predictor of bIMT.

Conclusions:

  • CKD is associated with elevated bIMT and heightened inflammatory activity.
  • bIMT is significantly correlated with systemic inflammation in CKD patients.
  • eGFR is a critical determinant of vascular remodeling (bIMT) in CKD.

Keywords:
ICAM-1IL-6TNFVCAM-1atherosclerosisendothelial functionflow-mediated dilatationintima-media thicknesspredialytic kidney failure

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