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Relationship between interdigestive gallbladder emptying, plasma motilin and migrating motor complex in man
B I Nilsson1, T Svenberg, T Tollström
1Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Acta Physiologica Scandinavica
|May 1, 1990
Summary
Biliary output stimulates motilin release and gastrointestinal motility. Gallbladder emptying, linked to motilin peaks, precedes migrating motor complex activity fronts, explaining fasted state fluctuations.
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- Plasma motilin concentration exhibits fluctuations in the fasted state.
- The role of biliary output in regulating gastrointestinal motility and motilin release is not fully understood.
Purpose of the Study:
- To investigate the relationship between biliary output and the regulation of the migrating motor complex (MMC).
- To determine the impact of biliary output on plasma motilin release.
Main Methods:
- Hepatobiliary scintigraphy monitored gallbladder emptying.
- Radioimmunoassay measured plasma motilin concentration.
- A perfused catheter system assessed gastrointestinal motility in 16 volunteers over 46 hours.
Main Results:
- 29 gallbladder emptying episodes correlated with 27 plasma motilin peaks and 23 MMC activity fronts.
- Biliary output was associated with a significant rise in plasma motilin.
- Plasma motilin decreased significantly following MMC activity fronts (phase 3).
- Gallbladder emptying episodes initiated transitions between MMC phases (1, 2, and 3).
Conclusions:
- A temporal relationship exists between biliary output into the duodenum and plasma motilin release.
- Biliary output stimulates gastrointestinal motility during the fasted state.
- This interplay explains the observed fluctuations in plasma motilin concentration.