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Aip1p Dynamics Are Altered by the R256H Mutation in Actin
Published on: July 30, 2014
Identification and characterization of the actinomycin G gene cluster in Streptomyces iakyrus
Xiaoling Wang1, Jioji Tabudravu, Mostafa Ezzat Rateb
1Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Aberdeen AB24 3LZ, Scotland, UK.
Abstract:
The gene cluster directing actinomycin G biosynthesis in Streptomyces iakyrus has been identified and sequenced. It contains one actinomycin synthetase I (ACMS I) gene and two copies of ACMS II and III genes. Genetic analysis demonstrates a unique partnership between the putative hydroxylation and chlorination activities as both acmG8 and acmG9 genes need to be transcribed for the biosynthesis of actinomycin G2-3, respectively.
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