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Updated: May 12, 2026

Measuring Psoriasis Severity at Home
Published on: March 1, 2024
The relationship between severity of the disease and circulating nucleosomes in psoriasis patients
Aziz Ramazan Dilek1, Nursel Dilek, Yunus Saral
1Microbiology Department of Recep Tayyip Erdoğan University, Medical Faculty Hospital, Rize, 53000, Turkey. ar.dilek@hotmail.com
Abstract:
Psoriasis was initially considered to represent a disease of abnormal epidermal keratinocyte proliferation. Proliferation of keratinocytes is restricted by apoptotic cell death to maintain a constant thickness of epidermis. Nucleosomes are mainly released by apoptotic cells. Tumor necrosis factor-α (TNF-α) is an important factor affecting the apoptosis. In the present study, the relationship between TNF-α, nucleosome and the Psoriasis Area and Severity Index (PASI) score was investigated. The patients were divided according to PASI score into three groups (mild, moderately, severe). Serum TNF-α and nucleosome levels were measured using Enzyme-linked immunosorbent assay (ELISA) method. Our findings show a correct relationship between PASI scores and TNF-α and an inverse relationship between nucleosome and PASI score. According to the results obtained from the study, we believe that serum nucleosome levels can be used as a new indicator in follow-up of patients with psoriasis and monitoring of the effectiveness of drugs which used in the treatment of psoriasis.
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