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Related Concept Videos

Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Classification and Mechanical Properties of Synthetic Polymers01:28

Classification and Mechanical Properties of Synthetic Polymers

Synthetic polymers are classified as elastomers, fibers, or plastics based on their crystallinity. Crystallinity, the degree of long-range order in the solid state, influences the mechanical properties (stretching or contracting) of elastomers. Elastomers are flexible polymers that can expand or contract easily upon the application of an external force. They have numerous crosslinks that pull them back into their original shape when stress is removed. Silicones, for instance, are highly elastic...
Microbial Bioremediation of Plastics01:28

Microbial Bioremediation of Plastics

Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...

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Updated: May 12, 2026

Designed for Molecular Recycling: A Lignin-Derived Semi-aromatic Biobased Polymer
10:22

Designed for Molecular Recycling: A Lignin-Derived Semi-aromatic Biobased Polymer

Published on: November 30, 2020

Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters.

Congcong Zhu1, Stephen R Kustra, Christopher J Bettinger

  • 1Department of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Acta Biomaterialia
|April 10, 2013
PubMed
Summary
This summary is machine-generated.

Researchers developed a new biodegradable elastomer, poly(glycerol-co-sebacate)-cinnamate (PGS-CinA), using food-derived monomers. This material supports cell growth and is suitable for bioabsorbable medical devices and tissue engineering scaffolds.

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The Preparation and Properties of Thermo-reversibly Cross-linked Rubber Via Diels-Alder Chemistry
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The Preparation and Properties of Thermo-reversibly Cross-linked Rubber Via Diels-Alder Chemistry

Published on: August 25, 2016

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Synthetic biodegradable elastomers are crucial for advancing bioabsorbable medical implants.
  • Current materials often require photoinitiators for crosslinking, limiting their application.
  • There is a need for novel elastomers with tunable properties and inherent biocompatibility.

Purpose of the Study:

  • To synthesize and characterize a novel photo-crosslinkable biodegradable elastomer, poly(glycerol-co-sebacate)-cinnamate (PGS-CinA).
  • To evaluate the mechanical properties, degradation profile, and cellular response of PGS-CinA networks.
  • To explore the potential of PGS-CinA for applications in medical devices and soft tissue engineering.

Main Methods:

  • Synthesis of hyperbranched polyesters derivatized with pendant cinnamate groups.
  • Photodimerization of PGS-CinA in the absence of photoinitiators.
  • Characterization of mechanical properties (Young's modulus) and in vitro degradation.
  • Assessment of fibroblast cell adhesion, spreading, and proliferation on PGS-CinA substrates.

Main Results:

  • PGS-CinA was successfully synthesized using food-derived monomers and photodimerization.
  • The resulting elastomer exhibited a Young's modulus ranging from 50.5 to 152.1 kPa.
  • In vitro degradation half-life was projected to be between 90 and 140 days.
  • PGS-CinA demonstrated intrinsic cell-adhesion properties and supported rapid fibroblast proliferation, influenced by substrate stiffness.

Conclusions:

  • PGS-CinA is a promising photo-crosslinkable biodegradable elastomer with tunable mechanical properties.
  • Its biocompatibility and degradation profile make it suitable for soft tissue engineering scaffolds.
  • PGS-CinA represents a next-generation material for bioabsorbable medical devices and regenerative medicine applications.