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Updated: Jan 2, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents
Fatma A Ragab1, Nagwa M Abdel Gawad, Hanan H Georgey
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, P.O. Box 11562, Cairo, Egypt.
Abstract:
Some novel 1,3,4-trisubstituted pyrazoles were synthesized and screened for their anti-inflammatory and analgesic activities as well as their ulcerogenic liability. They showed anti-inflammatory and analgesic activities with better GIT tolerance than the standard drug phenylbutazone. In addition, IC50 values for 5e and 8e were recorded. Compound 5e was found to be the most active one as anti-inflammatory and analgesic agent. On the other hand, COX-1/COX-2 isozyme selectivity was also done which showed equal inhibition to both isoforms.
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