Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Fluid Mosaic Model01:34

The Fluid Mosaic Model

The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strong correlation between phantomless and inline phantom-based densitometric calibration of vertebral properties from CT scans of healthy volunteers.

Frontiers in bioengineering and biotechnology·2026
Same author

In silico modeling of transcatheter heart valve oversizing and ellipticity, Part I: Establishing credibility of an advanced model.

Computer methods and programs in biomedicine·2026
Same author

Generation of 3D humanized vascularized and mineralized bone mimetic model via endochondral ossification.

Stem cell research·2026
Same author

Early intermittent low-dose sclerostin antibody treatment promotes surface bone formation and reduces bone loss, but also decreases osteocyte apoptosis and mechanotransduction in ovariectomized rats: A pilot study.

Bone reports·2026
Same author

In silico modeling of transcatheter heart valve oversizing and ellipticity, Part II: Effects on leaflet mechanics, hemodynamics, and stent deflection contributing to thrombogenic risk and structural degeneration.

Computer methods and programs in biomedicine·2026
Same author

Osteoblasts exert a pro-tumorigenic effect on breast cancer spheroids through CXCL5/CXCR2 signalling in two-dimensional and three-dimensional bone mimetic cultures.

Journal of the Royal Society, Interface·2026

Related Experiment Video

Updated: May 12, 2026

Analysis and Imaging of Osteocytes
10:19

Analysis and Imaging of Osteocytes

Published on: November 29, 2024

Fluid flow in the osteocyte mechanical environment: a fluid-structure interaction approach.

Stefaan W Verbruggen1, Ted J Vaughan, Laoise M McNamara

  • 1Biomechanics Research Centre (BMEC), Mechanical and Biomedical Engineering, College of Engineering and Informatics, National University of Ireland, Galway, Ireland.

Biomechanics and Modeling in Mechanobiology
|April 10, 2013
PubMed
Summary

Osteocytes, bone

More Related Videos

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
05:03

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Related Experiment Videos

Last Updated: May 12, 2026

Analysis and Imaging of Osteocytes
10:19

Analysis and Imaging of Osteocytes

Published on: November 29, 2024

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
05:03

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Area of Science:

  • Bone mechanobiology
  • Cellular biomechanics
  • Fluid-structure interaction

Background:

  • Osteocytes are key sensors of mechanical stimuli in bone.
  • Quantifying the cellular mechanical environment in vivo is challenging.
  • Previous models often simplify the fluid or solid bone environment.

Purpose of the Study:

  • To investigate the complex mechanical environment of osteocytes in vivo using fluid-structure interaction (FSI) modeling.
  • To develop geometrically accurate models of osteocytes based on in vivo visualization.
  • To predict fluid velocities and shear stresses experienced by osteocytes under physiological loading.

Main Methods:

  • Utilized fluorescent staining to visualize osteocyte environments.
  • Developed patient-specific, geometrically accurate computational models.
  • Employed fluid-structure interaction (FSI) simulations to model coupled fluid and solid domains.
  • Simulated physiological loading conditions representative of vigorous activity.

Main Results:

  • Predicted interstitial fluid velocities and maximum shear stresses surrounding osteocytes in vivo.
  • Identified that peak mechanical stimulation occurs around osteocyte cell processes within canaliculi.
  • Observed that simulated mechanical stimuli are within the range known to induce osteogenic responses.

Conclusions:

  • The study presents the first computational FSI models of the osteocyte mechanical environment in vivo.
  • Results highlight the significant role of cell processes in osteocyte mechanotransduction.
  • Findings enhance understanding of bone adaptation and mechanobiology.