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Updated: May 12, 2026
05:30
Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
Published on: October 31, 2025
[Gastric lymphoma: still an interdisciplinary challenge]
T F E Barth1, L Floßbach, P Möller
1Institut für Pathologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, 89070 Ulm, Deutschland.
Der Pathologe
|April 10, 2013
Summary
Differentiating chronic gastritis from MALT-type marginal zone B-cell lymphoma (MZoL) is challenging. New insights into blastic MZoL aid diagnosis and prognosis, distinguishing it from conventional diffuse large B-cell lymphomas (DLBCL).
Area of Science:
- Gastrointestinal pathology
- Hematopathology
- Oncology
Context:
- Distinguishing chronic gastritis from MALT-type marginal zone B-cell lymphoma (MZoL) poses diagnostic challenges for pathologists.
- Current diagnostic tools include CD20 staining, Wotherspoon grading, and B-cell clonality analysis.
Purpose:
- To discuss the challenges in diagnosing MZoL, particularly the blastic variant.
- To highlight the distinct clinical behavior and favorable prognosis of blastic MZoL compared to conventional diffuse large B-cell lymphomas (DLBCL).
- To review other gastric lymphomas, including conventional DLBCL, Burkitt lymphoma, B-CLL, mantle cell lymphoma, and T-cell lymphomas.
Summary:
- Marginal zone B-cell lymphoma of MALT type can transform into blastic MZoL, which may present with or without small cell MZoL.
- Blastic MZoL, despite being CD10-negative, is difficult to diagnose due to a lack of specific markers.
- Conventional gastric DLBCL, Burkitt lymphoma, B-CLL, mantle cell lymphoma, and T-cell lymphomas also occur in the stomach, with varying prognoses.
Impact:
- Improved diagnostic strategies for MZoL and its variants.
- Better understanding of the clinical outcomes for different gastric lymphomas.
- Potential for improved patient management and targeted therapies based on accurate diagnosis.
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