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Related Concept Videos

Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Vaccine Production01:23

Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Databases and in silico tools for vaccine design.

Yongqun He1, Zuoshuang Xiang

  • 1Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.

Methods in Molecular Biology (Clifton, N.J.)
|April 10, 2013
PubMed
Summary

Databases and in silico tools are essential for vaccine design, offering complementary roles in collecting data and predicting new vaccine components. The VIOLIN system integrates these resources for enhanced vaccine development.

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Area of Science:

  • Vaccinology
  • Bioinformatics
  • Computational Biology

Background:

  • Databases and in silico tools are crucial for modern vaccine design, serving distinct yet complementary functions.
  • Databases compile experimentally validated vaccines and components, while in silico tools offer computational methods for prediction and design.
  • Key vaccine components include antigens (proteins, epitopes), adjuvants, vectors, and preservatives.

Purpose of the Study:

  • To introduce databases and in silico tools that aid vaccine design.
  • To highlight the Vaccine Investigation and Online Information Network (VIOLIN) as a comprehensive resource.
  • To showcase Vaxign, a reverse vaccinology-based in silico vaccine design program within VIOLIN.

Main Methods:

  • Utilizing curated vaccine databases (e.g., FDA, USDA).
  • Employing in silico tools for computational vaccine design and analysis.
  • Integrating vaccine information with Vaccine Ontology (VO).

Main Results:

  • VIOLIN provides a comprehensive database of various vaccine types and components.
  • VIOLIN incorporates Vaxign, a web-based tool for in silico vaccine design.
  • The system facilitates the integration of diverse vaccine-related information.

Conclusions:

  • Databases and in silico tools are indispensable for efficient vaccine design.
  • The VIOLIN system offers a valuable integrated platform for vaccine research and development.
  • Leveraging such resources accelerates the discovery and design of novel vaccines.