Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A marker for primary choroid plexus neoplasms.

J Herbert1, T Cavallaro, A J Dwork

  • 1Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032.

The American Journal of Pathology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adrenarche as a regulator of sensitivity to early adversity.

Journal of neuroendocrinology·2026
Same author

Factors associated with early relapse of infantile haemangioma in children treated for at least six months with oral propranolol: A case-control study using the 2014-2021 French Ouest DataHub.

Annales de dermatologie et de venereologie·2023
Same author

Safety and efficacy of hysteroscopic resection of uterine leiomyoma embedded at the base of a uterine septum.

Facts, views & vision in ObGyn·2021
Same author

Incidence and outcomes of infective endocarditis after transcatheter aortic valve implantation versus surgical aortic valve replacement.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2020
Same author

Gut microbiome of treatment-naïve MS patients of different ethnicities early in disease course.

Scientific reports·2019
Same author

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Allergy·2016
Same journal

Lxrα Deficiency Primes Retinal Degeneration, but Aging Drives Disease Severity.

The American journal of pathology·2026
Same journal

MYC is functionally required in both normal and neoplastic Meibomian glands.

The American journal of pathology·2026
Same journal

Fumaric Acid Esters as Modulators of Ocular Inflammation and Angiogenesis.

The American journal of pathology·2026
Same journal

Krüppel-like factor 5 inhibition rescues cavernous nerve-injured erectile dysfunction by preventing phenotypic switch and mitochondrial dysfunction-dependent apoptosis in corpus cavernosum smooth muscle cells.

The American journal of pathology·2026
Same journal

APOE4 as a Modifier of Chemotherapy Response.

The American journal of pathology·2026
Same journal

Spatial Pathobiology in the Omics Era: Transforming Modern Pathology.

The American journal of pathology·2026
See all related articles

Transthyretin (TTR) is synthesized by choroid plexus (CP) tumors, making it a valuable diagnostic marker. This finding aids in distinguishing these rare brain tumors from other neoplasms.

Area of Science:

  • Neuro-oncology
  • Biochemical markers
  • Tumor pathology

Background:

  • Primary choroid plexus (CP) tumors are rare, with variable invasiveness.
  • Distinguishing CP tumors from metastatic or other primary brain tumors can be challenging.
  • Conventional cytologic markers lack specificity for accurate CP tumor diagnosis.

Purpose of the Study:

  • To investigate transthyretin (TTR) as a specific biochemical marker for primary CP tumors.
  • To evaluate the utility of TTR in differentiating CP neoplasms from other intracranial tumors.

Main Methods:

  • Immunohistochemical detection of TTR in tumor tissues.
  • In situ hybridization to confirm local TTR synthesis.
  • Comparison of TTR expression in CP tumors versus various other brain tumors and metastases.

Related Experiment Videos

Main Results:

  • Intense TTR immunoreactivity was observed in all nine primary CP tumors (papillomas and carcinomas).
  • TTR was not detected in ependymomas, meningiomas, oligodendrogliomas, astrocytomas, or most extracerebral papillary carcinomas and metastases.
  • TTR mRNA was abundant in neoplastic CP epithelium, confirming local synthesis.

Conclusions:

  • Transthyretin (TTR) is synthesized by neoplastic choroid plexus epithelium.
  • TTR serves as an excellent and specific marker for the diagnosis of primary CP neoplasms.