Related Experiment Video
Updated: May 12, 2026
05:55
Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats
Published on: September 27, 2024
Construction noise induces hypercoagulability and elevated plasma corticosteroids in rats
Mazen Toukh1, Sheila P Gordon1, Maha Othman2
1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
Summary
Construction noise significantly impacts research rat coagulation, causing stress-induced hypercoagulability. This highlights the need to monitor the acoustic environment in animal research, especially for hemostasis studies.
Area of Science:
- Veterinary Medicine
- Animal Physiology
- Biomedical Research
Background:
- Environmental factors like noise are often overlooked in animal research housing.
- Controlled environments typically focus on lighting, temperature, and humidity, neglecting acoustics.
- The impact of noise on physiological parameters, particularly hemostasis, requires further investigation.
Purpose of the Study:
- To investigate the effect of construction-induced noise on coagulation in healthy control rats.
- To determine if noise exposure induces stress responses affecting hemostasis.
- To assess the implications of acoustic environment monitoring in animal research.
Main Methods:
- A retrospective study design was employed.
- Thromboelastography (TEG) was used to analyze coagulation parameters in rats.
- Noise-exposed rats were compared to age- and gender-matched non-exposed control rats.
Main Results:
- Significant shortening of the reaction (R) time was observed in noise-exposed rats (P = .009).
- A trend toward an increased coagulation index (CI) was noted (P = .09), indicating hypercoagulability.
- Elevated plasma cortisol and corticosterone levels correlated with shortened R time and increased CI, confirming stress induction.
Conclusions:
- Construction noise acts as a significant stressor in research animals.
- Noise-induced stress leads to hypercoagulability in rats.
- Monitoring the acoustic environment is crucial for animal welfare and the validity of research, especially in hemostasis studies.
