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Updated: May 12, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Association between vascular endothelial growth factor +936 C/T gene polymorphism and age-related macular
Yanming Jiang1, Ge Liang, Liqiang Wang
1Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.
Objectives:
The pathogenesis of age-related macular degeneration (AMD) remains unknown. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and a target for inhibition therapy in wet AMD. This study investigated the association between the VEGF +936 C/T gene polymorphism and AMD, in a Chinese Han population.
Methods:
Patients with AMD, and age- and sex-matched controls were enrolled. Restriction fragment length polymorphism was used to analyse the VEGF +936 polymorphism in the promoter and the 3' untranslated region of the gene.
Results:
The study included 200 AMD patients and 200 control subjects. There was a significantly higher prevalence of the TT genotype among AMD patients (9.0%) compared with controls (3.5%); the odds ratio for this genotype in AMD patients was 2.73 (95% confidence intervals 1.11, 6.68). There were no significant associations between any genotype and AMD subphenotypic categories (early, geographic atrophy, choroidal neovascularization).
Conclusions:
The present study findings suggested that the VEGF +936 TT genotype was associated with AMD among Han Chinese patients.
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