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Updated: May 12, 2026
12:32
Quantification of Plasmid-Mediated Antibiotic Resistance in an Experimental Evolution Approach
Published on: December 14, 2019
Plasmid-mediated quinolone resistance--current knowledge and future perspectives
Xizhou Guan1, Xinying Xue, Yuxia Liu
1Department of Respiratory Diseases, Chinese PLA General Hospital, Beijing, China.
The Journal of International Medical Research
|April 10, 2013
Summary
Quinolone antibiotics are widely used, but resistance is increasing globally. This review focuses on plasmid-mediated resistance mechanisms, a significant challenge in antimicrobial therapy.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Quinolones, including fluoroquinolones, are broad-spectrum antimicrobials.
- Their widespread use has driven a global increase in antimicrobial resistance.
- Resistance mechanisms involve genetic mutations, cellular changes, and plasmid-mediated genes.
Purpose of the Study:
- To review the mechanisms of quinolone resistance.
- To emphasize the growing issue of plasmid-mediated quinolone resistance.
Main Methods:
- Literature review of quinolone resistance.
- Focus on plasmid-mediated resistance mechanisms.
Main Results:
- Quinolone resistance is a growing global concern.
- Plasmid-mediated resistance, identified in 1998 with qnrA1, is a key factor.
- Numerous other plasmid-mediated resistance genes have since been identified.
Conclusions:
- Understanding quinolone resistance, especially plasmid-mediated forms, is crucial.
- Continued research into resistance mechanisms is necessary for effective antimicrobial strategies.
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