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Frontotemporal dementia in southeast Asia: a comparative study.
Yee-Leng Tan1, Amanda Ng, Nagaendran Kandiah
1Department of Neurology, National Neuroscience Institute, Singapore.
Dementia and Geriatric Cognitive Disorders Extra
|April 10, 2013
Summary
Frontotemporal dementia (FTD) is a significant cause of young-onset dementia in Southeast Asia. This study characterized FTD patients, revealing behavioral variant FTD (bv-FTD) as the predominant subtype.
Area of Science:
- Neurology
- Neuroscience
- Geriatrics
Background:
- The clinical presentation of frontotemporal dementia (FTD) in Southeast Asia remains under-investigated.
- This study aimed to characterize and compare FTD patients in Southeast Asia with those in North Asia and Western countries.
Purpose of the Study:
- To define the demographic and clinical characteristics of frontotemporal dementia (FTD) in Southeast Asian patients.
- To compare these characteristics with North Asian and Western FTD cohorts.
Main Methods:
- Retrospective analysis of FTD patients (behavioral variant FTD and language variant FTD) diagnosed using Lund-Manchester criteria at a tertiary neurology institute.
- Characterization included demographics, clinical presentation, neuroimaging, and longitudinal follow-up data.
Main Results:
- A cohort of 25 bv-FTD and 19 lv-FTD patients was identified, with a 2:1 female predominance and a mean age of 56.
- The average Mini-Mental State Examination (MMSE) score was 16.2, with 88.4% experiencing memory symptoms.
- Over approximately 5 years, 60% of bv-FTD and 36.8% of lv-FTD patients developed a second FTD syndrome; bv-FTD was the most common subtype.
Conclusions:
- Frontotemporal dementia (FTD) is a notable cause of dementia in younger individuals in Southeast Asia.
- Increased awareness is crucial for timely diagnosis and effective management of FTD in the region.
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