Related Experiment Video
Updated: May 12, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
Published on: July 1, 2020
Mediastinitis: Could your case be a candidate for candida?
Bernadette Johnson1, Joshua Davis, Maria Sisneros
1University of New Mexico, Health Sciences Center, Albuquerque, NM, U.S.A.
Background:
Candida mediastinitis is rare, but mortality has been reported as high as 50%. There are no clinical trials evaluating treatment of Candida mediastinitis and there are only a limited number of reports in the literature.
Case Report:
We present two cases of mediastinitis after coronary artery bypass grafting due to Candida albicans. Immunosuppression and long surgical procedures were likely risk factors for the infections. After multiple hospitalizations and debridements there was concern for the development of resistance. However, the isolates were determined to be fluconazole-susceptible and the patients were treated with long-term oral fluconazole.
Conclusions:
Candida mediastinitis is difficult to treat. Even with appropriate treatment, patients may require numerous surgical debridements.
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