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Primary pediatric stage III renal diffuse large B-cell lymphoma.
Akira Hayakawa1, Nobuya Shimotake, Ikuko Kubokawa
1Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan.
The American Journal of Case Reports
|April 10, 2013
Summary
Primary renal lymphoma, a rare pediatric cancer, was successfully treated in a 12-year-old girl with diffuse large B-cell lymphoma. Prompt chemotherapy led to complete remission, highlighting the importance of considering this rare diagnosis for unusual kidney tumors.
Area of Science:
- Pediatric Oncology
- Nephrology
- Hematology
Background:
- Primary renal lymphoma is an exceptionally rare condition, distinct from secondary involvement of the kidney by non-Hodgkin lymphoma.
- Diffuse large B-cell lymphoma can manifest as a primary renal tumor, even in pediatric patients.
Purpose of the Study:
- To report a rare case of primary renal diffuse large B-cell lymphoma in a pediatric patient.
- To emphasize the diagnostic challenges and treatment outcomes for this rare entity.
Main Methods:
- A 12-year-old female presented with gross hematuria and a renal mass.
- Diagnostic workup included imaging, nephrectomy, and pathological examination confirming diffuse large B-cell lymphoma.
- Staging involved PET/CT, revealing secondary thyroid involvement. Treatment consisted of chemotherapy.
Main Results:
- Pathological examination confirmed diffuse large B-cell lymphoma of the kidney.
- The patient was diagnosed with stage III lymphoma after detecting thyroid involvement.
- Following chemotherapy, the patient achieved complete remission and remained disease-free for 3 years.
Conclusions:
- Primary renal lymphoma is a rare diagnosis that can be challenging to identify preoperatively.
- Given its aggressive nature, primary renal lymphoma should be considered in the differential diagnosis of pediatric renal tumors.
- This case demonstrates a favorable outcome with timely chemotherapy.
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