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Antinociceptive activity of Ricinus communis L. leaves
Dnyaneshwar J Taur1, Maruti G Waghmare, Rajendra S Bandal
1Department of Pharmacognosy, SVPM's College of Pharmacy, Malegaon (bk), Baramati, Maharashtra, India.
Asian Pacific Journal of Tropical Biomedicine
|April 10, 2013
Summary
The methanol extract of Ricinus communis leaves (MRCL) shows significant pain-relieving effects in mice. This antinociceptive activity may be attributed to the presence of saponins, steroids, and alkaloids in the extract.
Area of Science:
- Pharmacology
- Ethnobotany
Background:
- Ricinus communis, commonly known as castor oil plant, has traditional uses in pain management.
- Scientific validation of its analgesic properties is essential.
Purpose of the Study:
- To investigate the antinociceptive (pain-relieving) effects of the methanol extract of Ricinus communis leaves (MRCL).
Main Methods:
- The study utilized three established pain models in mice: acetic acid-induced writhing, formalin-induced paw licking, and tail immersion.
- The MRCL was administered at doses of 100, 125, and 150 mg/kg body weight.
Main Results:
- MRCL demonstrated significant antinociceptive activity across all three pain models.
- Preliminary phytochemical screening of MRCL revealed the presence of saponins, steroids, and alkaloids.
Conclusions:
- The methanol extract of Ricinus communis leaves possesses notable antinociceptive potential.
- The observed pain-relieving effects are likely mediated by the identified phytochemical constituents: saponins, steroids, and alkaloids.
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