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A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
Published on: November 15, 2024
Antinociceptive activity of Ricinus communis L. leaves
Dnyaneshwar J Taur1, Maruti G Waghmare, Rajendra S Bandal
1Department of Pharmacognosy, SVPM's College of Pharmacy, Malegaon (bk), Baramati, Maharashtra, India.
Objective:
To evaluate the antinociceptive activity of the methanol extract of Ricinus communis leaves (MRCL).
Methods:
Antinociceptive activity was evaluated using acetic acid induced writhing test, formalin induced paw licking and tail immersion method in mice at doses of 100, 125 and 150 mg/kg bw.
Results:
The results indicated that MRCL exhibited considerable antinociceptive activity against three classical models of pain in mice. Preliminary phytochemical analysis suggested the presence of saponin, steroids and alkaloids.
Conclusions:
It can be concluded that MRCL possesses antinociceptive potential that may be due to saponin, steroids and alkaloids in it.
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