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Increased serum nitric oxide and malondialdehyde levels in patients with acute intestinal amebiasis
E S Namıduru1, M Tarakçıoğlu, M Namıduru
1University of Gaziantep, Faculty of Medicine, Department of Biochemistry, Gaziantep, Turkey.
Objective:
To determine the level of oxygen-nitrogen stress parameters in the pathogenesis of amebiasis.
Methods:
Twenty-four acute intestinal amebiasis patients and 20 healthy controls were enrolled in the present study. Serum malondialdehyde and nitric oxide levels were determined spectrophotometrically.
Results:
Serum malondialdehyde and nitric oxide levels were significantly higher in acute intestinal amebiasis patients than healthy controls (P<0.001).
Conclusions:
These results suggest that oxidative and nitrosative stress may play a major role in tissue damage in acute intestinal amebiasis patients. Also these parameters can be used to supplement the conventional microscopic method for reliable diagnosis of intestinal amebiasis.
