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Anti-inflammatory and analgesic activities of Melanthera scandens
Jude E Okokon1, Anwanga E Udoh, Samuel G Frank
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Objective:
To evaluate the anti-inflammatory and analgesic activities of leaf extract of Melanthera scandens (M. scandens).
Methods:
The crude leaf extract (39-111 mg/kg) of M. scandens was investigated for anti-inflammatory and analgesic activities using various experimental models. The anti-inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property.
Results:
The extract caused a significant (P<0.05 - 0.001) dose-dependent reduction of inflammation and pains induced by different agents used.
Conclusions:
The leaf extract possesses anti-inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant.