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Updated: May 12, 2026
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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
Published on: July 20, 2019
Immunomodulatory effects of interferons in malignancies
Joseph Bekisz1, Yuki Sato, Chase Johnson
1Cytokine Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD 20892, USA.
Summary
Interferon (IFN) exhibits antitumor and immune-stimulating properties, showing promise in treating certain cancers. Combining IFN with monocytes may enhance efficacy against malignancies.
Area of Science:
- Immunology
- Oncology
- Virology
Background:
- Interferon (IFN) research for antitumor and immunomodulatory effects began in 1957.
- Early studies demonstrated IFN's ability to inhibit viral leukemia in mice and improve survival.
- Purified IFNs confirmed immune cell stimulation leading to direct and indirect antitumor activities.
Purpose of the Study:
- To review the role of interferon (IFN) and monocytes in cancer.
- To explore the therapeutic potential of IFN-alphas (αs) in various malignancies.
- To investigate the combined effects of IFN and monocytes on cancer treatment.
Main Methods:
- Literature review of studies on interferon and monocytes in cancer.
- Analysis of clinical data on IFN-alpha efficacy.
- Examination of the role of monocytes/macrophages in cancer progression.
Main Results:
- IFN-alphas (αs) have shown clinical activity against several tumors, with FDA approval for specific cancers.
- Treatment success with IFNs varies, and some neoplasms do not respond.
- Monocytes/macrophages are crucial in cancer progression, suggesting a potential therapeutic role when combined with IFN.
Conclusions:
- Interferon (IFN) demonstrates antitumor and immunomodulatory capabilities.
- The combination of IFN with monocytes presents a potential therapeutic strategy for various cancers.
- Further investigation into IFN and monocyte interactions is warranted for optimizing cancer treatment.
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