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Severe skin toxicity in pediatric oncology patients treated with voriconazole and concomitant methotrexate
Johan G C van Hasselt1, Natasha K A van Eijkelenburg, Alwin D R Huitema
1Department of Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Abstract:
We report the occurrence of skin toxicities in pediatric oncology patients on concomitant treatment with voriconazole and methotrexate (MTX). Of 23 patients who received this combination, 11 patients suffered from cheilitis and/or photosensitivity. In contrast, only in 1 of 9 patients who received voriconazole without MTX was photosensitivity observed. A mechanism of action was not able to be identified. We describe two cases with severe skin toxicities. Caution is warranted when using voriconazole and concomitant MTX.
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