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Biopharmaceutical Factors Influencing Drug Product Design: Overview01:22

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though pharmacologically...

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Related Experiment Video

Updated: May 12, 2026

3D Printing of Preclinical X-ray Computed Tomographic Data Sets
11:06

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Published on: March 22, 2013

Three-dimensional drug printing: a structured review.

Iulia D Ursan1, Ligia Chiu, Andrea Pierce

  • 1College of Pharmacy, University of Illinois at Chicago, M/C 874, 833 S. Wood St., Chicago, IL 60612, USA. iursan2@uic.edu

Journal of the American Pharmacists Association : Japha
|April 11, 2013
PubMed
Summary
This summary is machine-generated.

Three-dimensional (3D) printing technologies offer precise control for pharmaceutical manufacturing, enabling personalized medications. This review highlights the potential of 3D printing (3DP) to transform drug delivery and pharmacy practice.

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Area of Science:

  • Pharmaceutical Manufacturing
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Three-dimensional printing (3DP) is an emerging technology with significant potential in pharmaceutical manufacturing.
  • Existing literature explores various 3DP technologies for drug fabrication and delivery.

Purpose of the Study:

  • To review current 3D printing technologies used in pharmaceutical manufacturing.
  • To identify limitations of 3D printing in drug production.
  • To highlight the future potential of 3D printing in pharmacy practice.

Main Methods:

  • A systematic literature search was conducted on PubMed and Embase from January 1990 to August 2012.
  • Search terms included "drug printing," "drug 3D printing," and "drug three-dimensional printing."
  • Original research articles on 3D printing for drug manufacturing were included and analyzed.

Main Results:

  • Twenty-one articles were included, focusing on inkjet and powder-based printing technologies.
  • These methods demonstrated precise droplet control, high reproducibility, and the ability to create complex drug release profiles.
  • 3DP facilitates personalized medication therapy and offers advantages in drug development and fabrication.

Conclusions:

  • Individualized medications produced via 3D printing (3DP) promise significant patient benefits.
  • Printable dosage forms, particularly paper-based, may offer improved delivery compared to powder-based forms.
  • Medications with narrow therapeutic indices or those influenced by genetic polymorphisms are prime candidates for initial 3DP applications.